Welcome

Welcome to The Home Page for The Salem Laboratory of Advanced Drug and Gene Delivery. Dr. Salem's research interests are primarily focused on self-assembling systems, the rational design of novel drug and gene delivery systems and on the development of vaccines that stimulate potent antigen-specific immune responses.  Dr Salem's laboratory applies microfabrication techniques to develop novel drug and gene delivery devices and to optimize control over polymer-cell interactions . The group is currently exploring the synergistic application of polymer particle technology, CpG oligonucleotides, modified RNA, virus like particles, and adenoviruses for generating sustained stronger immune responses against tumors. The group is also working on new materials based methods and approaches for enhancing tissue regeneration.

 

Selected Publication Highlights:

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022. 

K. Ebeid, X. Meng, K.W. Thiel, A. Do, S.M. Geary, A. S. Morris, E.L. Pham, A. Wongrakpanich, Y.S. Chhonker, D.J. Murry, K.K. Leslie, A.K. Salem. Synthetically Lethal Nanoparticles for Treatment of Endometrial Cancer. Nature Nanotechnology. 2018.

M.C. Coleman, J.E. Goetz, M.J. Brouillette, D. Seol, M.C. Willey, E.B. Petersen, B. Khorsand, A.S. Morris, A.K. Salem, D.C. Fredericks, T.O. McKinley, J.A. Martin. Mitochondrial Responses to Intraarticular Fracture are a Disease-Modifying Target for Posttraumatic Osteoarthritis Prevention. Science Translational Medicine. 2018.

S.M. Geary, C.D. Lemke, D.M. Lubaroff and A.K. Salem. Proposed mechanisms of action for prostate cancer vaccines. Nature Reviews Urology. 2013.

A.K. Salem, P.C. Searson and K.W. Leong. Multifunctional nanorods for gene delivery. Nature Materials. Oct 2003, 2, 668-671.

H.S. Sakhalkar, M.K. Dalal, A.K. Salem, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and D.J. Goetz. Leukocyte inspired therapeutic particles that selectively and avidly adhere to inflamed endothelium. Proceedings of the National Academy of Sciences.100 (26): 15895-15900 DEC 23 2003.

 

Iowa v Northern Illinois in football at Kinnick Stadium - 01 Sep 2018

Formulation Expertise

Our research group has expertise in formulating small molecules, proteins and nucleic acids

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Materials Science and Nano and Microtechnology Expertise

Our research group has expertise on materials characterization and using nano and microtechnology to develop effective dosage forms.

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Formulation

Experts

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Drug and Gene Delivery

Toxicity Testing

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Cancer Immunotherapy

Regenerative Medicine

Directions

See the "Contact Us" page for directions to the College of Pharmacy

 

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Research in progress 1

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022.

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Research in progress 2

S. Areecheewakul, A. Adamcakova-Dodd, Z.R. Zacharias, X. Jing, D.K. Meyerholz, K.L. Legge, J.C.D. Houtman, P.T. O’Shaughnessy, P.S. Thorne, A.K. Salem. Immunomodulatory effects of sub-acute inhalation exposure to copper oxide nanoparticles in house dust mite-induced asthma. ACS Nano. 2023.

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Events

2024 College of Pharmacy White Coat Ceremony promotional image

2024 College of Pharmacy White Coat Ceremony

Saturday, August 24, 2024 10:00am to 11:30am
Hancher Auditorium
The College of Pharmacy will host a special ceremony to welcome the Class of 2028 into the pharmacy profession and college family on Aug. 24. This event is sponsored by Walgreens.
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Study Abroad Fair

Tuesday, September 17, 2024 11:00am to 3:00pm
Iowa Memorial Union (IMU)
Get your questions answered and kick-start your global experience at the University of Iowa fall Study Abroad Fair!
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College of Pharmacy Homecoming Week

Thursday, October 24 to Saturday, October 26, 2024 (all day)
Join us during Homecoming Week as we honor alumni/friends and celebrate with each other! More information regarding events coming this summer! Oct. 24, TBD - Osterhaus Lifetime Achievement Symposium and Alumni Awards Ceremony College of Pharmacy Building, Iowa City Oct. 25, 5:45 pm - Homecoming Parade  Downtown Iowa City Oct. 25, 7:00 pm - Alumni, Family, and Friends Celebration The Graduate Hotel, Iowa City Oct. 26, 2:30 pm - Homecoming Football Game vs. Northwestern Kinnick Stadium...

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