Welcome

Welcome to The Home Page for The Salem Laboratory of Advanced Drug and Gene Delivery. Dr. Salem's research interests are primarily focused on self-assembling systems, the rational design of novel drug and gene delivery systems and on the development of vaccines that stimulate potent antigen-specific immune responses.  Dr Salem's laboratory applies microfabrication techniques to develop novel drug and gene delivery devices and to optimize control over polymer-cell interactions . The group is currently exploring the synergistic application of polymer particle technology, CpG oligonucleotides, modified RNA, virus like particles, and adenoviruses for generating sustained stronger immune responses against tumors. The group is also working on new materials based methods and approaches for enhancing tissue regeneration.

 

Selected Publication Highlights:

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022. 

K. Ebeid, X. Meng, K.W. Thiel, A. Do, S.M. Geary, A. S. Morris, E.L. Pham, A. Wongrakpanich, Y.S. Chhonker, D.J. Murry, K.K. Leslie, A.K. Salem. Synthetically Lethal Nanoparticles for Treatment of Endometrial Cancer. Nature Nanotechnology. 2018.

M.C. Coleman, J.E. Goetz, M.J. Brouillette, D. Seol, M.C. Willey, E.B. Petersen, B. Khorsand, A.S. Morris, A.K. Salem, D.C. Fredericks, T.O. McKinley, J.A. Martin. Mitochondrial Responses to Intraarticular Fracture are a Disease-Modifying Target for Posttraumatic Osteoarthritis Prevention. Science Translational Medicine. 2018.

S.M. Geary, C.D. Lemke, D.M. Lubaroff and A.K. Salem. Proposed mechanisms of action for prostate cancer vaccines. Nature Reviews Urology. 2013.

A.K. Salem, P.C. Searson and K.W. Leong. Multifunctional nanorods for gene delivery. Nature Materials. Oct 2003, 2, 668-671.

H.S. Sakhalkar, M.K. Dalal, A.K. Salem, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and D.J. Goetz. Leukocyte inspired therapeutic particles that selectively and avidly adhere to inflamed endothelium. Proceedings of the National Academy of Sciences.100 (26): 15895-15900 DEC 23 2003.

 

Iowa v Northern Illinois in football at Kinnick Stadium - 01 Sep 2018

Formulation Expertise

Our research group has expertise in formulating small molecules, proteins and nucleic acids

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Materials Science and Nano and Microtechnology Expertise

Our research group has expertise on materials characterization and using nano and microtechnology to develop effective dosage forms.

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Formulation

Experts

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Drug and Gene Delivery

Toxicity Testing

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Cancer Immunotherapy

Regenerative Medicine

Directions

See the "Contact Us" page for directions to the College of Pharmacy

 

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Research in progress 1

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022.

See Publications for Full List
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Research in progress 2

S. Areecheewakul, A. Adamcakova-Dodd, Z.R. Zacharias, X. Jing, D.K. Meyerholz, K.L. Legge, J.C.D. Houtman, P.T. O’Shaughnessy, P.S. Thorne, A.K. Salem. Immunomodulatory effects of sub-acute inhalation exposure to copper oxide nanoparticles in house dust mite-induced asthma. ACS Nano. 2023.

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Events

Healing Horizons: A Journey into Indigenous Spirituality, Culture, and Global Well-being promotional image

Healing Horizons: A Journey into Indigenous Spirituality, Culture, and Global Well-being

Thursday, April 18, 2024 12:00pm to 1:00pm
University Capitol Centre
This talk will delve into Indigenous healing processes that emphasize interconnectedness. Sessions will explore the compatibility of individuals with others, the spiritual world, and the social structure. The holistic approach to health will be highlighted, showcasing how Indigenous health interventions address individual care and encompass activities aimed at restoring social and spiritual balance.
ACVP Philanthropy Event at Safe Haven Animal Shelter promotional image

ACVP Philanthropy Event at Safe Haven Animal Shelter

Saturday, April 20, 2024 1:30pm to 4:30pm
Safe Haven of Iowa County Animal Shelter
College of Pharmacy students from the American College of Veterinary Pharmacists will volunteer at the Safe Haven of Iowa County Animal Shelter. Pharmacy students can sign up here
Roots of Resilience: Preserving Cultures, Languages, and Health promotional image

Roots of Resilience: Preserving Cultures, Languages, and Health

Tuesday, April 23, 2024 12:00pm to 1:00pm
University Capitol Centre
This talk will explore various facets of cultural preservation, including discussing language revitalization efforts of the Kalinago language and strategies to ensure its survival and transmission to future generations.

Use navigation links to see publications and current group members

Links also show available equipment, former group members and collaborators