Welcome

Welcome to the home page for "The Salem Laboratory of Advanced Drug and Gene Delivery". Dr. Salem's research expertise is in drug discovery, development, formulation and delivery. Dr. Salem applies this expertise to developing therapies for regenerative medicine, cancer and other diseases. 

 

Selected Publication Highlights:

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022. 

K. Ebeid, X. Meng, K.W. Thiel, A. Do, S.M. Geary, A. S. Morris, E.L. Pham, A. Wongrakpanich, Y.S. Chhonker, D.J. Murry, K.K. Leslie, A.K. Salem. Synthetically Lethal Nanoparticles for Treatment of Endometrial Cancer. Nature Nanotechnology. 2018.

M.C. Coleman, J.E. Goetz, M.J. Brouillette, D. Seol, M.C. Willey, E.B. Petersen, B. Khorsand, A.S. Morris, A.K. Salem, D.C. Fredericks, T.O. McKinley, J.A. Martin. Mitochondrial Responses to Intraarticular Fracture are a Disease-Modifying Target for Posttraumatic Osteoarthritis Prevention. Science Translational Medicine. 2018.

S.M. Geary, C.D. Lemke, D.M. Lubaroff and A.K. Salem. Proposed mechanisms of action for prostate cancer vaccines. Nature Reviews Urology. 2013.

A.K. Salem, P.C. Searson and K.W. Leong. Multifunctional nanorods for gene delivery. Nature Materials. Oct 2003, 2, 668-671.

H.S. Sakhalkar, M.K. Dalal, A.K. Salem, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and D.J. Goetz. Leukocyte inspired therapeutic particles that selectively and avidly adhere to inflamed endothelium. Proceedings of the National Academy of Sciences.100 (26): 15895-15900 DEC 23 2003.

 

porous particle

Formulation Expertise

Our research group has expertise in formulating small molecules, proteins and nucleic acids

Pyramid Scaffold

Materials Science and Nano and Microtechnology Expertise

Our research group has expertise on materials characterization and using nano and microtechnology to develop effective dosage forms.

Salem Group 2016

Formulation

Experts
In the Lab 2

Drug and Gene Delivery

Toxicity Testing
Kareem Salem

Cancer Immunotherapy

Regenerative Medicine

Directions

See the "Contact Us" page for directions to the College of Pharmacy

 

cells with particles

Research in progress 1

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022.

3D Salem Lab logo

Research in progress 2

S. Areecheewakul, A. Adamcakova-Dodd, Z.R. Zacharias, X. Jing, D.K. Meyerholz, K.L. Legge, J.C.D. Houtman, P.T. O’Shaughnessy, P.S. Thorne, A.K. Salem. Immunomodulatory effects of sub-acute inhalation exposure to copper oxide nanoparticles in house dust mite-induced asthma. ACS Nano. 2023.

News

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Events

UI College of Pharmacy Reception at AAPS PharmSci 360 promotional image

UI College of Pharmacy Reception at AAPS PharmSci 360

Monday, November 10, 2025 6:00pm to 8:00pm
Grand Hyatt San Antonio River Walk, Travis Room A/B

Heading to AAPS PharmSci 360 in November? We’d love for you to join us for a casual reception hosted by the UI College of Pharmacy and the Department of Pharmaceutical Sciences and Experimental Therapeutics on Nov. 10. It’s a great chance to catch up with alumni and colleagues. Be sure to RSVP!

IPA Student Pharmacist Practice Forum promotional image

IPA Student Pharmacist Practice Forum

Wednesday, November 12, 2025 6:00pm to 7:00pm
Virtual

Come learn about standard of care and what it means for you as a future pharmacist. Iowa Pharmacy Association (IPA) Student Board of Trustee members Ian Patterson (University of Iowa) and Stacy Johnson (Drake University) will facilitate this interactive virtual forum with IPA Executive Fellow Spencer Short, PharmD. Bring your questions and thoughts as time is available for good discussion. The forum is open to all student pharmacist members of IPA

2025 Three Minute Thesis Competition promotional image

2025 Three Minute Thesis Competition

Thursday, November 13, 2025 1:30pm to 3:30pm
Iowa Memorial Union (IMU)

The University of Iowa’s Three Minute Thesis (3MT) competition challenges graduate students to clearly and concisely articulate complex research to nonspecialist audiences.
Join us on Nov. 13 at the Iowa Memorial Union (IMU) International Ballroom.

The 3MT competition will be held from 1:30 to 3:30 p.m. in the IMU International Ballroom (2nd floor). Join us to see our amazing 3MT finalists present their incredible research at the final competition. This event is open to the entire UI campus and...

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