Welcome

Welcome to the home page for "The Salem Laboratory of Advanced Drug and Gene Delivery". Dr. Salem's research expertise is in drug discovery, development, formulation and delivery. Dr. Salem applies this expertise to developing therapies for regenerative medicine, cancer and other diseases. 

 

Selected Publication Highlights:

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022. 

K. Ebeid, X. Meng, K.W. Thiel, A. Do, S.M. Geary, A. S. Morris, E.L. Pham, A. Wongrakpanich, Y.S. Chhonker, D.J. Murry, K.K. Leslie, A.K. Salem. Synthetically Lethal Nanoparticles for Treatment of Endometrial Cancer. Nature Nanotechnology. 2018.

M.C. Coleman, J.E. Goetz, M.J. Brouillette, D. Seol, M.C. Willey, E.B. Petersen, B. Khorsand, A.S. Morris, A.K. Salem, D.C. Fredericks, T.O. McKinley, J.A. Martin. Mitochondrial Responses to Intraarticular Fracture are a Disease-Modifying Target for Posttraumatic Osteoarthritis Prevention. Science Translational Medicine. 2018.

S.M. Geary, C.D. Lemke, D.M. Lubaroff and A.K. Salem. Proposed mechanisms of action for prostate cancer vaccines. Nature Reviews Urology. 2013.

A.K. Salem, P.C. Searson and K.W. Leong. Multifunctional nanorods for gene delivery. Nature Materials. Oct 2003, 2, 668-671.

H.S. Sakhalkar, M.K. Dalal, A.K. Salem, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and D.J. Goetz. Leukocyte inspired therapeutic particles that selectively and avidly adhere to inflamed endothelium. Proceedings of the National Academy of Sciences.100 (26): 15895-15900 DEC 23 2003.

 

porous particle

Formulation Expertise

Our research group has expertise in formulating small molecules, proteins and nucleic acids

Pyramid Scaffold

Materials Science and Nano and Microtechnology Expertise

Our research group has expertise on materials characterization and using nano and microtechnology to develop effective dosage forms.

Salem Group 2016

Formulation

Experts

In the Lab 2

Drug and Gene Delivery

Toxicity Testing

Kareem Salem

Cancer Immunotherapy

Regenerative Medicine

Directions

See the "Contact Us" page for directions to the College of Pharmacy

 

cells with particles

Research in progress 1

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022.

3D Salem Lab logo

Research in progress 2

S. Areecheewakul, A. Adamcakova-Dodd, Z.R. Zacharias, X. Jing, D.K. Meyerholz, K.L. Legge, J.C.D. Houtman, P.T. O’Shaughnessy, P.S. Thorne, A.K. Salem. Immunomodulatory effects of sub-acute inhalation exposure to copper oxide nanoparticles in house dust mite-induced asthma. ACS Nano. 2023.

News

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Events

Three Minute Thesis: Final Competition promotional image

Three Minute Thesis: Final Competition

Thursday, November 7, 2024 12:00pm to 3:00pm
Iowa Memorial Union (IMU)
The University of Iowa’s Three Minute Thesis (3MT) competition challenges graduate students to clearly and concisely articulate complex research to nonspecialist audiences. Join us on Nov. 7th at the Iowa Memorial Union (IMU).   City High research scholars reception will take place from noon-12:45 in the Black Box Theater (3rd floor - IMU). The 3MT competition is from 1-3 in the Iowa Theater (1st floor). Join to see our amazing 3MT finalists present their incredible research at the final competition. This event is open to all of UI campus and community!
Celebrating Excellence: Honoring Teachers, Preceptors, and Staff of the Year promotional image

Celebrating Excellence: Honoring Teachers, Preceptors, and Staff of the Year

Friday, November 8, 2024 12:30pm to 1:30pm
College of Pharmacy Building
College of Pharmacy faculty, staff, and students are invited to honor the 2023-24 teachers, preceptors, and staff of the year on Nov. 8.  We will celebrate with a short program at 12:30 p.m., followed by a dessert reception.  Faculty/Staff/Students/Alumni: Please RSVP at this linkCollegiate Teacher of the Year, Mary Schroeder Class of 2027 Teacher of the Year, Nicole Brogden Class of 2026 Teacher of the Year, Michelle Fravel Class of 2025 Teacher of the Year, James Hoehns APPE...

College of Pharmacy PSET Seminar Series: Jon Selbo, PhD

Tuesday, November 12, 2024 11:30am
College of Pharmacy Building
The Department of Pharmaceutical Sciences and Experimental Therapeutics in the College of Pharmacy will host a seminar presented by:  Jon Selbo, PhD Senior Research Advisor Synthetic Molecular Design and Development Eli Lilly Noblesville, Indiana All are welcome to attend.

Use navigation links to see publications and current group members

Links also show available equipment, former group members and collaborators