Welcome

Welcome to the home page for "The Salem Laboratory of Advanced Drug and Gene Delivery". Dr. Salem's research expertise is in drug discovery, development, formulation and delivery. Dr. Salem applies this expertise to developing therapies for regenerative medicine, cancer and other diseases. 

 

Selected Publication Highlights:

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022. 

K. Ebeid, X. Meng, K.W. Thiel, A. Do, S.M. Geary, A. S. Morris, E.L. Pham, A. Wongrakpanich, Y.S. Chhonker, D.J. Murry, K.K. Leslie, A.K. Salem. Synthetically Lethal Nanoparticles for Treatment of Endometrial Cancer. Nature Nanotechnology. 2018.

M.C. Coleman, J.E. Goetz, M.J. Brouillette, D. Seol, M.C. Willey, E.B. Petersen, B. Khorsand, A.S. Morris, A.K. Salem, D.C. Fredericks, T.O. McKinley, J.A. Martin. Mitochondrial Responses to Intraarticular Fracture are a Disease-Modifying Target for Posttraumatic Osteoarthritis Prevention. Science Translational Medicine. 2018.

S.M. Geary, C.D. Lemke, D.M. Lubaroff and A.K. Salem. Proposed mechanisms of action for prostate cancer vaccines. Nature Reviews Urology. 2013.

A.K. Salem, P.C. Searson and K.W. Leong. Multifunctional nanorods for gene delivery. Nature Materials. Oct 2003, 2, 668-671.

H.S. Sakhalkar, M.K. Dalal, A.K. Salem, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and D.J. Goetz. Leukocyte inspired therapeutic particles that selectively and avidly adhere to inflamed endothelium. Proceedings of the National Academy of Sciences.100 (26): 15895-15900 DEC 23 2003.

 

porous particle

Formulation Expertise

Our research group has expertise in formulating small molecules, proteins and nucleic acids

Pyramid Scaffold

Materials Science and Nano and Microtechnology Expertise

Our research group has expertise on materials characterization and using nano and microtechnology to develop effective dosage forms.

Salem Group 2016

Formulation

Experts

In the Lab 2

Drug and Gene Delivery

Toxicity Testing

Kareem Salem

Cancer Immunotherapy

Regenerative Medicine

Directions

See the "Contact Us" page for directions to the College of Pharmacy

 

cells with particles

Research in progress 1

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022.

3D Salem Lab logo

Research in progress 2

S. Areecheewakul, A. Adamcakova-Dodd, Z.R. Zacharias, X. Jing, D.K. Meyerholz, K.L. Legge, J.C.D. Houtman, P.T. O’Shaughnessy, P.S. Thorne, A.K. Salem. Immunomodulatory effects of sub-acute inhalation exposure to copper oxide nanoparticles in house dust mite-induced asthma. ACS Nano. 2023.

News

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Events

College of Pharmacy PSET Seminar Series: Daniel Crona, PharmD, PhD, CPP promotional image

College of Pharmacy PSET Seminar Series: Daniel Crona, PharmD, PhD, CPP

Tuesday, April 8, 2025 11:30am
College of Pharmacy Building
The Department of Pharmaceutical Sciences and Experimental Therapeutics in the College of Pharmacy will host a seminar presented by: Daniel Crona, PharmD, PhD, CPPAssociate ProfessorDivision of Pharmacotherapy and Experimental TherapeuticsUniversity of North Carolina at Chapel HillSeminar Title: "A First-In-Class Chemical-Induced Proximity System Achieves Dose-Dependent Control of TP53 Activation in Preclinical Models of Gastric Cancer"All are welcome to attend.
College of Pharmacy at UI Hawkeye Caucus 2025 promotional image

College of Pharmacy at UI Hawkeye Caucus 2025

Wednesday, April 9, 2025 (all day)
Iowa State Capitol
Hawkeye Caucus Day is a day to highlight the accomplishments the University of Iowa is making in Iowa City and across the state at the State Capitol in Des Moines. It’s a unique, once-a-year chance for UI faculty, staff, and students to meet with legislators as they showcase the university’s continued commitment to statewide service.
College of Pharmacy PSET Thesis Seminar: Emese Kovacs promotional image

College of Pharmacy PSET Thesis Seminar: Emese Kovacs

Friday, April 11, 2025 8:00am
Medical Education Research Facility
The Department of Pharmaceutical Sciences and Experimental Therapeutics in the College of Pharmacy will host a thesis seminar presented by PhD student Emese Kovacs. Thesis Title: "Elucidating the Role of DNA Methylation in Bipolar Disorder in the Context of Suicide Attempt and Lithium Use" All are welcome to attend.

Use navigation links to see publications and current group members

Links also show available equipment, former group members and collaborators