Welcome

Welcome to the home page for "The Salem Laboratory of Advanced Drug and Gene Delivery". Dr. Salem's research expertise is in drug discovery, development, formulation and delivery. Dr. Salem applies this expertise to developing therapies for regenerative medicine, cancer and other diseases. 

 

Selected Publication Highlights:

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022. 

K. Ebeid, X. Meng, K.W. Thiel, A. Do, S.M. Geary, A. S. Morris, E.L. Pham, A. Wongrakpanich, Y.S. Chhonker, D.J. Murry, K.K. Leslie, A.K. Salem. Synthetically Lethal Nanoparticles for Treatment of Endometrial Cancer. Nature Nanotechnology. 2018.

M.C. Coleman, J.E. Goetz, M.J. Brouillette, D. Seol, M.C. Willey, E.B. Petersen, B. Khorsand, A.S. Morris, A.K. Salem, D.C. Fredericks, T.O. McKinley, J.A. Martin. Mitochondrial Responses to Intraarticular Fracture are a Disease-Modifying Target for Posttraumatic Osteoarthritis Prevention. Science Translational Medicine. 2018.

S.M. Geary, C.D. Lemke, D.M. Lubaroff and A.K. Salem. Proposed mechanisms of action for prostate cancer vaccines. Nature Reviews Urology. 2013.

A.K. Salem, P.C. Searson and K.W. Leong. Multifunctional nanorods for gene delivery. Nature Materials. Oct 2003, 2, 668-671.

H.S. Sakhalkar, M.K. Dalal, A.K. Salem, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and D.J. Goetz. Leukocyte inspired therapeutic particles that selectively and avidly adhere to inflamed endothelium. Proceedings of the National Academy of Sciences.100 (26): 15895-15900 DEC 23 2003.

 

porous particle

Formulation Expertise

Our research group has expertise in formulating small molecules, proteins and nucleic acids

Pyramid Scaffold

Materials Science and Nano and Microtechnology Expertise

Our research group has expertise on materials characterization and using nano and microtechnology to develop effective dosage forms.

Salem Group 2016

Formulation

Experts

In the Lab 2

Drug and Gene Delivery

Toxicity Testing

Kareem Salem

Cancer Immunotherapy

Regenerative Medicine

Directions

See the "Contact Us" page for directions to the College of Pharmacy

 

cells with particles

Research in progress 1

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022.

3D Salem Lab logo

Research in progress 2

S. Areecheewakul, A. Adamcakova-Dodd, Z.R. Zacharias, X. Jing, D.K. Meyerholz, K.L. Legge, J.C.D. Houtman, P.T. O’Shaughnessy, P.S. Thorne, A.K. Salem. Immunomodulatory effects of sub-acute inhalation exposure to copper oxide nanoparticles in house dust mite-induced asthma. ACS Nano. 2023.

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Events

Syllabus Savvy: Communicating AI Expectations promotional image

Syllabus Savvy: Communicating AI Expectations

Thursday, June 26, 2025 10:30am to 11:30am
College of Pharmacy Building
Learn how to model clear instructions about AI use, ways to create AI disclosure statements, and suggestions for maintaining ongoing conversations about your AI policies.Register for event.The Office of Teaching, Learning, and Technology provides expertise, tools, and services to optimize teaching and learning through learning sciences research, ICON, teaching and learning data, and advanced classroom and instructional technology. To learn more about the services we offer, please visit our...
Antimicrobial Stewardship Series: Antimicrobial Stewardship in Dental Practice: Principles and Practice promotional image

Antimicrobial Stewardship Series: Antimicrobial Stewardship in Dental Practice: Principles and Practice

Friday, June 27, 2025 12:00pm to 1:00pm
Virtual
Iowa Statewide Antimicrobial Stewardship Initiative – a partnership between Iowa Health and Human Services and UI College of Pharmacy in conjunction with the UI Carver College of Medicine Department of Continuing Education present the following seminar by Karen Baker, MS:"Antimicrobial Stewardship Series: Antimicrobial Stewardship in Dental Practice: Principles and Practice"Continuing education available.
Summer Health Professions Education Program:  Pharmacy Track promotional image

Summer Health Professions Education Program: Pharmacy Track

Wednesday, July 2, 2025 12:30pm to 4:30pm
College of Pharmacy Building
The College of Pharmacy will educate undergraduate students through the pharmacy track of the UI The Summer Health Professions Education Program (SHPEP), on Wednesdays, June 11 – July 16. This free, six-week summer enrichment program is focused on improving access to information and resources for undergraduate students interested in health professions.Pharmacy-track students are hearing about pharmacy career paths and the academic experiences that led professionals to their chosen career...

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