Welcome

Welcome to the home page for "The Salem Laboratory of Advanced Drug and Gene Delivery". Dr. Salem's research expertise is in drug discovery, development, formulation and delivery. Dr. Salem applies this expertise to developing therapies for regenerative medicine, cancer and other diseases. 

 

Selected Publication Highlights:

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022. 

K. Ebeid, X. Meng, K.W. Thiel, A. Do, S.M. Geary, A. S. Morris, E.L. Pham, A. Wongrakpanich, Y.S. Chhonker, D.J. Murry, K.K. Leslie, A.K. Salem. Synthetically Lethal Nanoparticles for Treatment of Endometrial Cancer. Nature Nanotechnology. 2018.

M.C. Coleman, J.E. Goetz, M.J. Brouillette, D. Seol, M.C. Willey, E.B. Petersen, B. Khorsand, A.S. Morris, A.K. Salem, D.C. Fredericks, T.O. McKinley, J.A. Martin. Mitochondrial Responses to Intraarticular Fracture are a Disease-Modifying Target for Posttraumatic Osteoarthritis Prevention. Science Translational Medicine. 2018.

S.M. Geary, C.D. Lemke, D.M. Lubaroff and A.K. Salem. Proposed mechanisms of action for prostate cancer vaccines. Nature Reviews Urology. 2013.

A.K. Salem, P.C. Searson and K.W. Leong. Multifunctional nanorods for gene delivery. Nature Materials. Oct 2003, 2, 668-671.

H.S. Sakhalkar, M.K. Dalal, A.K. Salem, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and D.J. Goetz. Leukocyte inspired therapeutic particles that selectively and avidly adhere to inflamed endothelium. Proceedings of the National Academy of Sciences.100 (26): 15895-15900 DEC 23 2003.

 

porous particle

Formulation Expertise

Our research group has expertise in formulating small molecules, proteins and nucleic acids

Pyramid Scaffold

Materials Science and Nano and Microtechnology Expertise

Our research group has expertise on materials characterization and using nano and microtechnology to develop effective dosage forms.

Salem Group 2016

Formulation

Experts

In the Lab 2

Drug and Gene Delivery

Toxicity Testing

Kareem Salem

Cancer Immunotherapy

Regenerative Medicine

Directions

See the "Contact Us" page for directions to the College of Pharmacy

 

cells with particles

Research in progress 1

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022.

3D Salem Lab logo

Research in progress 2

S. Areecheewakul, A. Adamcakova-Dodd, Z.R. Zacharias, X. Jing, D.K. Meyerholz, K.L. Legge, J.C.D. Houtman, P.T. O’Shaughnessy, P.S. Thorne, A.K. Salem. Immunomodulatory effects of sub-acute inhalation exposure to copper oxide nanoparticles in house dust mite-induced asthma. ACS Nano. 2023.

News

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Events

Healthiest State Initiative Walk promotional image

Healthiest State Initiative Walk

Wednesday, October 1, 2025 12:00am to 11:59pm
Campus Recreation and Wellness Center
Walk on October 1, 2025 to make Iowa the healthiest state! The University of Iowa supports the Healthiest State Walk as a state-wide initiative to make Iowa the healthiest state in the nation.The Healthiest State Initiative's 15th Annual Walk encourages Iowans to walk for 30 minutes on Wednesday, October 1. The theme is #StartSomewhere. You don’t have to be a marathon runner to take care of your mental and physical health. What matters is that you start somewhere, whether that be a daily walk or...
NSF I-Corps Workshop promotional image

NSF I-Corps Workshop

Monday, October 6, 2025 4:00pm to 6:00pm
Virtual
The NSF I-Corps program at the University of Iowa, led by the John Pappajohn Entrepreneurial Center (Iowa JPEC), helps researchers, innovators, and early-stage startups explore the commercial potential of their work and make a real impact in the world.
College of Pharmacy PSET Seminar Series: Kristina Thiel, PhD promotional image

College of Pharmacy PSET Seminar Series: Kristina Thiel, PhD

Tuesday, October 7, 2025 11:30am
College of Pharmacy Building
The Department of Pharmaceutical Sciences and Experimental Therapeutics (PSET) in the College of Pharmacy will host a seminar presented by: Kristina Thiel, PhDAssistant ProfessorDepartment of Obstetrics and GynecologyUniversity of IowaIowa City, IowaSeminar Title: "Hormone Therapy for Endometrial Cancer"All are welcome to attend. No pre-registration required.

Use navigation links to see publications and current group members

Links also show available equipment, former group members and collaborators