Welcome

Welcome to the home page for "The Salem Laboratory of Advanced Drug and Gene Delivery". Dr. Salem's research expertise is in drug discovery, development, formulation and delivery. Dr. Salem applies this expertise to developing therapies for regenerative medicine, cancer and other diseases. 

 

Selected Publication Highlights:

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022. 

K. Ebeid, X. Meng, K.W. Thiel, A. Do, S.M. Geary, A. S. Morris, E.L. Pham, A. Wongrakpanich, Y.S. Chhonker, D.J. Murry, K.K. Leslie, A.K. Salem. Synthetically Lethal Nanoparticles for Treatment of Endometrial Cancer. Nature Nanotechnology. 2018.

M.C. Coleman, J.E. Goetz, M.J. Brouillette, D. Seol, M.C. Willey, E.B. Petersen, B. Khorsand, A.S. Morris, A.K. Salem, D.C. Fredericks, T.O. McKinley, J.A. Martin. Mitochondrial Responses to Intraarticular Fracture are a Disease-Modifying Target for Posttraumatic Osteoarthritis Prevention. Science Translational Medicine. 2018.

S.M. Geary, C.D. Lemke, D.M. Lubaroff and A.K. Salem. Proposed mechanisms of action for prostate cancer vaccines. Nature Reviews Urology. 2013.

A.K. Salem, P.C. Searson and K.W. Leong. Multifunctional nanorods for gene delivery. Nature Materials. Oct 2003, 2, 668-671.

H.S. Sakhalkar, M.K. Dalal, A.K. Salem, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and D.J. Goetz. Leukocyte inspired therapeutic particles that selectively and avidly adhere to inflamed endothelium. Proceedings of the National Academy of Sciences.100 (26): 15895-15900 DEC 23 2003.

 

porous particle

Formulation Expertise

Our research group has expertise in formulating small molecules, proteins and nucleic acids

Pyramid Scaffold

Materials Science and Nano and Microtechnology Expertise

Our research group has expertise on materials characterization and using nano and microtechnology to develop effective dosage forms.

Salem Group 2016

Formulation

Experts

In the Lab 2

Drug and Gene Delivery

Toxicity Testing

Kareem Salem

Cancer Immunotherapy

Regenerative Medicine

Directions

See the "Contact Us" page for directions to the College of Pharmacy

 

cells with particles

Research in progress 1

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022.

3D Salem Lab logo

Research in progress 2

S. Areecheewakul, A. Adamcakova-Dodd, Z.R. Zacharias, X. Jing, D.K. Meyerholz, K.L. Legge, J.C.D. Houtman, P.T. O’Shaughnessy, P.S. Thorne, A.K. Salem. Immunomodulatory effects of sub-acute inhalation exposure to copper oxide nanoparticles in house dust mite-induced asthma. ACS Nano. 2023.

News

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Events

College of Pharmacy PSET Seminar Series: Christian Fernandez, PhD promotional image

College of Pharmacy PSET Seminar Series: Christian Fernandez, PhD

Tuesday, October 28, 2025 11:30am
College of Pharmacy Building

The Department of Pharmaceutical Sciences and Experimental Therapeutics (PSET) in the College of Pharmacy will host a seminar presented by: 

Christian Fernandez, PhD
Associate Professor
Department of Pharmaceutical Sciences
University of Pittsburgh
Pittsburg, Pennsylvania

All are welcome to attend. No pre-registration required.

Seminar Title: "NFAT Inhibitors for Improving Immunogenicity: From Target Identification to Drug Development"

Celebrating Excellence: Honoring Teachers, Preceptors, and Staff of the Year

Thursday, October 30, 2025 12:30pm to 1:30pm
College of Pharmacy Building

College of Pharmacy faculty, staff, and students are invited to honor the 2025-26 teachers, preceptors, and staff of the year on Oct. 30.  We will celebrate with a short program at 12:30 p.m., followed by a dessert reception. 

Collegiate Teacher of the Year, Lewis Stevens

Class of 2028 Teacher of the Year, Jeff Reist

Class of 2027 Teacher of the Year, Erika Ernst

Class of 2026 Teacher of the Year, Matt Cantrell

APPE Preceptor Excellence Award, Tony Huynh

IPPE Preceptor Excellence Award, James Lyon

Facu...

College of Pharmacy PSET Seminar Series: Tonglei Li, PhD promotional image

College of Pharmacy PSET Seminar Series: Tonglei Li, PhD

Tuesday, November 4, 2025 11:30am
College of Pharmacy Building

The Department of Pharmaceutical Sciences and Experimental Therapeutics (PSET) in the College of Pharmacy will host a seminar presented by: 

Tonglei Li, PhD
Allen Chao Chair and Professor
Industrial and Physical Pharmacy
Purdue University
West Lafayette, Indiana

All are welcome to attend. No pre-registration required.

Seminar Title: "Manifold Learning of Molecular Quantum Information"

Use navigation links to see publications and current group members

Links also show available equipment, former group members and collaborators