Welcome

Welcome to the home page for "The Salem Laboratory of Advanced Drug and Gene Delivery". Dr. Salem's research expertise is in drug discovery, development, formulation and delivery. Dr. Salem applies this expertise to developing therapies for regenerative medicine, cancer and other diseases. 

 

Selected Publication Highlights:

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022. 

K. Ebeid, X. Meng, K.W. Thiel, A. Do, S.M. Geary, A. S. Morris, E.L. Pham, A. Wongrakpanich, Y.S. Chhonker, D.J. Murry, K.K. Leslie, A.K. Salem. Synthetically Lethal Nanoparticles for Treatment of Endometrial Cancer. Nature Nanotechnology. 2018.

M.C. Coleman, J.E. Goetz, M.J. Brouillette, D. Seol, M.C. Willey, E.B. Petersen, B. Khorsand, A.S. Morris, A.K. Salem, D.C. Fredericks, T.O. McKinley, J.A. Martin. Mitochondrial Responses to Intraarticular Fracture are a Disease-Modifying Target for Posttraumatic Osteoarthritis Prevention. Science Translational Medicine. 2018.

S.M. Geary, C.D. Lemke, D.M. Lubaroff and A.K. Salem. Proposed mechanisms of action for prostate cancer vaccines. Nature Reviews Urology. 2013.

A.K. Salem, P.C. Searson and K.W. Leong. Multifunctional nanorods for gene delivery. Nature Materials. Oct 2003, 2, 668-671.

H.S. Sakhalkar, M.K. Dalal, A.K. Salem, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and D.J. Goetz. Leukocyte inspired therapeutic particles that selectively and avidly adhere to inflamed endothelium. Proceedings of the National Academy of Sciences.100 (26): 15895-15900 DEC 23 2003.

 

porous particle

Formulation Expertise

Our research group has expertise in formulating small molecules, proteins and nucleic acids

Pyramid Scaffold

Materials Science and Nano and Microtechnology Expertise

Our research group has expertise on materials characterization and using nano and microtechnology to develop effective dosage forms.

Salem Group 2016

Formulation

Experts

In the Lab 2

Drug and Gene Delivery

Toxicity Testing

Kareem Salem

Cancer Immunotherapy

Regenerative Medicine

Directions

See the "Contact Us" page for directions to the College of Pharmacy

 

cells with particles

Research in progress 1

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022.

3D Salem Lab logo

Research in progress 2

S. Areecheewakul, A. Adamcakova-Dodd, Z.R. Zacharias, X. Jing, D.K. Meyerholz, K.L. Legge, J.C.D. Houtman, P.T. O’Shaughnessy, P.S. Thorne, A.K. Salem. Immunomodulatory effects of sub-acute inhalation exposure to copper oxide nanoparticles in house dust mite-induced asthma. ACS Nano. 2023.

News

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Events

The Upstream Approach to Healthcare Lecture Series Presents Jonathan Platt promotional image

The Upstream Approach to Healthcare Lecture Series Presents Jonathan Platt

Wednesday, November 20, 2024 12:00pm to 1:00pm
Virtual
The date and time for this lecture are Wednesday, Nov. 20, from noon to 1 p.m. This lecture will be offered both in person and over Zoom. If you attend in person, please go to room B111 in the Medical Laboratories. Food and drinks be provided! If you would like to attend in person, please sign up at the link provided: https://www.signupgenius.com/go/10C0C4AADAF2AA2FCC16-52448065-theupstream If you would like to attend virtually, please register via the Zoom link: https://uiowa.zoom.us/meeting...

Imposter Syndrome - Addressing the Fear of Being a Fraud

Monday, December 2, 2024 12:30pm
College of Pharmacy Building
The College of Pharmacy Office of Professional Education is sponsoring a lecture discussion on “Imposter Syndrome – Addressing the Fear of Being a Fraud” on Monday, Dec. 2 at 12:30 p.m. in 210 CPB. Barry Schreier, PhD, director of Higher Education Programming for the Scanlan Center for School Mental Health and Clinical Professor of Counseling Psychology for the University of Iowa College of Education, will be facilitating this discussion. This workshop will assist you with learning: The...

College of Pharmacy PSET Seminar Series: Colin Kenny, PhD

Tuesday, December 3, 2024 11:30am
College of Pharmacy Building
The Department of Pharmaceutical Sciences and Experimental Therapeutics in the College of Pharmacy will host a seminar presented by:  Colin Kenny, PhD Assistant Professor Department of Anatomy and Cell Biology University of Iowa All are welcome to attend.

Use navigation links to see publications and current group members

Links also show available equipment, former group members and collaborators