Welcome

Welcome to the home page for "The Salem Laboratory of Advanced Drug and Gene Delivery". Dr. Salem's research expertise is in drug discovery, development, formulation and delivery. Dr. Salem applies this expertise to developing therapies for regenerative medicine, cancer and other diseases. 

 

Selected Publication Highlights:

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022. 

K. Ebeid, X. Meng, K.W. Thiel, A. Do, S.M. Geary, A. S. Morris, E.L. Pham, A. Wongrakpanich, Y.S. Chhonker, D.J. Murry, K.K. Leslie, A.K. Salem. Synthetically Lethal Nanoparticles for Treatment of Endometrial Cancer. Nature Nanotechnology. 2018.

M.C. Coleman, J.E. Goetz, M.J. Brouillette, D. Seol, M.C. Willey, E.B. Petersen, B. Khorsand, A.S. Morris, A.K. Salem, D.C. Fredericks, T.O. McKinley, J.A. Martin. Mitochondrial Responses to Intraarticular Fracture are a Disease-Modifying Target for Posttraumatic Osteoarthritis Prevention. Science Translational Medicine. 2018.

S.M. Geary, C.D. Lemke, D.M. Lubaroff and A.K. Salem. Proposed mechanisms of action for prostate cancer vaccines. Nature Reviews Urology. 2013.

A.K. Salem, P.C. Searson and K.W. Leong. Multifunctional nanorods for gene delivery. Nature Materials. Oct 2003, 2, 668-671.

H.S. Sakhalkar, M.K. Dalal, A.K. Salem, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and D.J. Goetz. Leukocyte inspired therapeutic particles that selectively and avidly adhere to inflamed endothelium. Proceedings of the National Academy of Sciences.100 (26): 15895-15900 DEC 23 2003.

 

porous particle

Formulation Expertise

Our research group has expertise in formulating small molecules, proteins and nucleic acids

Pyramid Scaffold

Materials Science and Nano and Microtechnology Expertise

Our research group has expertise on materials characterization and using nano and microtechnology to develop effective dosage forms.

Salem Group 2016

Formulation

Experts

In the Lab 2

Drug and Gene Delivery

Toxicity Testing

Kareem Salem

Cancer Immunotherapy

Regenerative Medicine

Directions

See the "Contact Us" page for directions to the College of Pharmacy

 

cells with particles

Research in progress 1

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022.

3D Salem Lab logo

Research in progress 2

S. Areecheewakul, A. Adamcakova-Dodd, Z.R. Zacharias, X. Jing, D.K. Meyerholz, K.L. Legge, J.C.D. Houtman, P.T. O’Shaughnessy, P.S. Thorne, A.K. Salem. Immunomodulatory effects of sub-acute inhalation exposure to copper oxide nanoparticles in house dust mite-induced asthma. ACS Nano. 2023.

News

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Events

Summer Health Professions Education Program:  Pharmacy Track promotional image

Summer Health Professions Education Program: Pharmacy Track

Wednesday, July 16, 2025 12:30pm to 4:30pm
College of Pharmacy Building
The College of Pharmacy will educate undergraduate students through the pharmacy track of the UI The Summer Health Professions Education Program (SHPEP), on Wednesdays, June 11 – July 16. This free, six-week summer enrichment program is focused on improving access to information and resources for undergraduate students interested in health professions.Pharmacy-track students are hearing about pharmacy career paths and the academic experiences that led professionals to their chosen career...
Faculty/Staff and Alumni Dinner at AACP Annual Meeting promotional image

Faculty/Staff and Alumni Dinner at AACP Annual Meeting

Sunday, July 20, 2025 6:00pm to 8:00pm
Sweetwater Tavern & Grille
Join fellow pharmacy alumni and faculty/staff for a dinner, hosted by the College of Pharmacy, at AACP Annual Meeting in Chicago. Contact Alumni Relations Manager Kayla Sanders (kayla-sanders@uiowa.edu) for more information.
College of Pharmacy Class of 2029 Professional Engagement Week promotional image

College of Pharmacy Class of 2029 Professional Engagement Week

Monday, August 18 to Friday, August 22, 2025 (all day)
College of Pharmacy Building
The College of Pharmacy will welcome the class of 2029 during Professional Engagement Week.

Use navigation links to see publications and current group members

Links also show available equipment, former group members and collaborators