Welcome

Welcome to The Home Page for The Salem Laboratory of Advanced Drug and Gene Delivery. Dr. Salem's research interests are primarily focused on self-assembling systems, the rational design of novel drug and gene delivery systems and on the development of vaccines that stimulate potent antigen-specific immune responses.  Dr Salem's laboratory applies microfabrication techniques to develop novel drug and gene delivery devices and to optimize control over polymer-cell interactions . The group is currently exploring the synergistic application of polymer particle technology, CpG oligonucleotides, modified RNA, virus like particles, and adenoviruses for generating sustained stronger immune responses against tumors. The group is also working on new materials based methods and approaches for enhancing tissue regeneration.

 

Selected Publication Highlights:

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022. 

K. Ebeid, X. Meng, K.W. Thiel, A. Do, S.M. Geary, A. S. Morris, E.L. Pham, A. Wongrakpanich, Y.S. Chhonker, D.J. Murry, K.K. Leslie, A.K. Salem. Synthetically Lethal Nanoparticles for Treatment of Endometrial Cancer. Nature Nanotechnology. 2018.

M.C. Coleman, J.E. Goetz, M.J. Brouillette, D. Seol, M.C. Willey, E.B. Petersen, B. Khorsand, A.S. Morris, A.K. Salem, D.C. Fredericks, T.O. McKinley, J.A. Martin. Mitochondrial Responses to Intraarticular Fracture are a Disease-Modifying Target for Posttraumatic Osteoarthritis Prevention. Science Translational Medicine. 2018.

S.M. Geary, C.D. Lemke, D.M. Lubaroff and A.K. Salem. Proposed mechanisms of action for prostate cancer vaccines. Nature Reviews Urology. 2013.

A.K. Salem, P.C. Searson and K.W. Leong. Multifunctional nanorods for gene delivery. Nature Materials. Oct 2003, 2, 668-671.

H.S. Sakhalkar, M.K. Dalal, A.K. Salem, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and D.J. Goetz. Leukocyte inspired therapeutic particles that selectively and avidly adhere to inflamed endothelium. Proceedings of the National Academy of Sciences.100 (26): 15895-15900 DEC 23 2003.

 

Iowa v Northern Illinois in football at Kinnick Stadium - 01 Sep 2018

Formulation Expertise

Our research group has expertise in formulating small molecules, proteins and nucleic acids

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Materials Science and Nano and Microtechnology Expertise

Our research group has expertise on materials characterization and using nano and microtechnology to develop effective dosage forms.

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Formulation

Experts

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Drug and Gene Delivery

Toxicity Testing

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Cancer Immunotherapy

Regenerative Medicine

Directions

See the "Contact Us" page for directions to the College of Pharmacy

 

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Research in progress 1

R. Smith†, E.I. Wafa†, S.M. Geary†, K. Ebeid, S.O. Alhaj-Suliman, A.K. Salem. Cationic nanoparticles enhance T-cell tumor infiltration and antitumor immune response to a melanoma vaccine. Science Advances. 2022.

See Publications for Full List
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Research in progress 2

S. Areecheewakul, A. Adamcakova-Dodd, Z.R. Zacharias, X. Jing, D.K. Meyerholz, K.L. Legge, J.C.D. Houtman, P.T. O’Shaughnessy, P.S. Thorne, A.K. Salem. Immunomodulatory effects of sub-acute inhalation exposure to copper oxide nanoparticles in house dust mite-induced asthma. ACS Nano. 2023.

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Events

College of Pharmacy All PODS Math Review promotional image

College of Pharmacy All PODS Math Review

Thursday, March 28, 2024 12:20pm to 1:30pm
College of Pharmacy Building
The College of Pharmacy PODS will host a math review for PharmD students. Come enjoy some burritos and prepare for your upcoming math exam! A worksheet will be provided with practice math questions covering the most commonly missed problems as well as a "cheat sheet" to aid in studying. In addition, we ask that P3s who attend help answer questions and tutor students if needed. We encourage anyone who attends to bring two canned foods to donate to the UI food pantry and help fellow students...
Society of Hospital Medicine Meeting: "Updates on Antibiotic Drug Allergy," w/Amy Dowden and Deanna McDanel promotional image

Society of Hospital Medicine Meeting: "Updates on Antibiotic Drug Allergy," w/Amy Dowden and Deanna McDanel

Thursday, March 28, 2024 12:30pm to 1:30pm
Virtual
The Society of Hospital Medicine (SHM) Iowa Chapter will be hosting a virtual meeting on Thursday, March 28 at 12:30 pm CT over Zoom. Please join for an educational presentation titled "Updates on Antibiotic Drug Allergy," provided by Amy Dowden and Deanna McDanel. Speakers: Amy Dowden, MD, MME Clinical Professor, University of Iowa Carver College of Medicine Deanna McDanel, PharmD, BCPS, BCACP Clinical Pharmacy Specialist, Ambulatory Care Clinical Associate Professor, University of...
UI-SSHP Philanthropy Event with Solon Senior Center promotional image

UI-SSHP Philanthropy Event with Solon Senior Center

Saturday, March 30, 2024 9:00am to 12:00pm
Solon Methodist Church
College of Pharmacy student members of the University of Iowa Student Society of Health-System Pharmacists (UI-SSHP) will host a Brown Bag event for residents of the Solon Senior Center at the Solon Methodist Church. Student pharmacists will answer medication-related questions and help dispose of unwanted or expired medications. Pharmacy students can sign up here to volunteer.

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Links also show available equipment, former group members and collaborators